Metastatic pheochromocytoma to liver without elevation of metanephrines and catecholamines

Plasma Metanephrines in the Diagnosis of Pheochromocytoma

Plasma metanephrines in the diagnosis of pheochromocytoma.

OBJECTIVE To examine whether tests for plasma metanephrines, the o-methylated metabolites of catecholamines, offer advantages for diagnosis of a pheochromocytoma over standard tests for plasma catecholamines or urinary metanephrines. DESIGN Cross-sectional study. SETTING 3 clinical specialist centers. PATIENTS 52 patients with a pheochromocytoma; 67 normotensive persons and 51 patients wi...

Disappearance rate of catecholamines, total metanephrines, and neuropeptide Y from the plasma of patients after resection of pheochromocytoma.

BACKGROUND Plasma free metanephrines are a more reliable analyte to measure than catecholamines for the biochemical diagnosis of pheochromocytomas. We hypothesized that the long persistence of total (sulfate-conjugated plus free) metanephrines in the blood might have a significant diagnostic value. METHODS We measured plasma concentrations of catecholamines and total metanephrines (sulfate-co...

Urinary and Plasma Catecholamines and Metanephrines in Dogs with Pheochromocytoma, Hypercortisolism, Nonadrenal Disease and in Healthy Dogs

BACKGROUND Diagnosis of pheochromocytoma (PC) is based on a combination of clinical suspicion, finding an adrenal mass, increased plasma, and urine concentrations of catecholamine metabolites and is finally confirmed with histopathology. In human medicine, it is controversial whether biochemically testing plasma is superior to testing urine. OBJECTIVES To measure urinary and plasma catecholam...

Plasma Free Metanephrines as Diagnostic Markers of Pheochromocytoma

Quantitative determination of catecholamines and their O-methyl metabolites plays an important role in the diagnosis of pheochromocytoma (PHEO) – adrenal medulla tumour. This kind of tumour synthesizes, stocks, metabolizes and mostly secretes catecholamines. For this reason it is possible to use elevated concentrations of catecholamines and their metabolic products from plasma and urine as diag...